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11 worth our devotion. 8-1362 Fri.;(/\ Street. TGEX R.W THERAPY AND ITS PRACTlLAl. 'PLICATION IN MALIGNANT LESIONS Do You Need A Prescription To Order Cialis From Canada By Dr. Rudis-Jicinskv, Cedar Rapids, Iowa. ry Rontgenologist knows that after several s and exposures of epitheliomata, cylindrical carcinomata, carcinomata simplex, and fiat carcinomata changes take place in the lesions with various metamorphoses or degenera- pointing to the fact that the Rontgen rays. ; the selective power for diseased cells espe- in some individual cases, are of objective eutical value, and if nothing more used prop- id in proper doses will give subjective results '■ "lalignant case whetiier they are combined •■ative procedures or not, because thev at • e the suffering of the patient and pro- In some cases when the Rontgen' rays >tered over a sufficient length of time, the very promising, and we have many case> of epithelioma especially, in which the after five or six years, are still dn- sll, and even patients with inojjerable deep and those of carcinoma mamnicC under icatment progressed well and no metastases tointoxications took place, the prognosis be- "pa ratively good. And strange to say, as mfciing of the American Rontgen Rav ."^ocietv. Ii<-I I ' h.. September 20. .10. October 1. loi".' you all certainly have observed in your practice, these promising conditions happen in all those le- sions rayed, in which the electrochemical action of the rays is complete and the intercellular tissue in the lesions exposed becomes so abundant as to near- ly obliterate the cellular elements, the hard portions of these carcinomata becoming softer or even lique- fied and show honeylike discharge, or an exudate demonstrates itself at all the points of the sloughing, the tissues undergoing spontaneous cure, perhaps, in this way. In that respect we have all the same ex- perience, I am sure, even in fibrocarcinomata, but not so in carcinoma molle. And again we seem to have better changes in deeper colloid carcinoma, myxomatodes, and melanocarcinomata. Having in mind the honeylike substance in nearly all the open lesions, which progressed favorably, and reading the reports of others on the same subject, I have carried out a number of experinients to see if I could cause a certain reaction or hasten the process of absorption under the Rontgen rays with the help of this seemingly healthy exudate which has some very active properties. First, I implanted under the skin this honeylike exudate from the human cancerous lesions into the tissues of rabbits and guineapigs. Relatively large quantities of this substance were planted under the skin into healthy tissues of these animals without causing any symptoms of reaction, and only in three cases out of twenty I had local infection, which did not amount to very much; but if a very small quan- tity of such a substance of cancer of a rabbit was inoculated into the tissues of old rabbits or those suffering with any wasting disease or injury, very definite symptoms were produced. The temperature rose from one to two degrees F. at once, and this rise was accompanied locally by inflammation. This process was observed for a length of time carefully, and microscopical examinations were made. The basement substance of various layers of connective tissue, and especially the walls of the bloodvessels, became swollen and thickened by their conversion into a translucent, firm, glassy, yellowish material, albuminous in character. The parts of the lesion felt harder than normal and had a peculiar, dull shining appearance. Some direct transformation of the tissues progressed rapidly, the parenchyma cells undergoing atrophy, as the result of pressure from the swollen, degenerated tissue. Around each lo- calized lesion produced was an area, more or less marked, of heat and redness, Do You Need A Prescription To Order Cialis From Canada and with the increas- ing congestion, we had later a casting otf of pieces of necrotic tissue, forming of a tumor, the cells of which, advancing in the periphery, made their way through the lymph spaces and formed new foci. In some cases metastasis followed in the distant part of the body, or general, and another tumor was formed. .\nd these secondary tumors being similar in structure to the primary foci differed in vascu- larity, abundance of stroma, and shape of the cells, I)ut nearly all of them seemed to be rapid in growth, if irritated in any way. When this condition was recognized the Rontgen rays were employed at once, and the animals were exposed individually first for fifteen minutes every day for two weeks, and then three times a week, and folliiwing the reaction we fiiiallv healed all the 174 RUDIS-JICINSKV: ROENTGEN RAY IN CANCER. (Xew Vobk medical joors, primary lesions produced ; but the lesions of sec- Do You Need A Prescription To Order Cialis From Canada ondary character, Do You Need A Prescription To Order Cialis From Canada of the epithelium of the part in which they occurred, varying much in this and other respects in every case, did not behave in the same way. We operated in quite a few of these lesions once or twice, as the cases required, con- tinuing the use of the Rontgen rays, but the final results were not satisfactory at all. although the animals did not seem to suffer much pain. As a last resort, knowing that phagocytes were dissemi- nated after an irritation in these lesions, we applied the honeylike exudate, produced in the primary le- sions direct to the malignant tumors of secondary character, or reinoculation of the disease in the same animal, and to our astonishment found that the sloughing progressed more rapidly and with better Do You Need A Prescription To Order Cialis From Canada results, the effect of our raying being more